![]() Based on animal studies, it is speculated that the benefit of CSs therapy in brain and spinal cord, include neuroprotection from free radicals, specifically when given at a higher supraphysiologic doses. The application of CSs in neurologic diseases, range from traumatic head and spinal cord injuries to central nervous system infections. There are considerable safety concerns associated with administering these drugs and should be limited to specific conditions in which their benefits outweigh the risks. Despite their broad use, limited evidence exists for their efficacy in diseases confronted in the neurocritical care setting. Corticosteroids (CSs) are used frequently in the neurocritical care unit mainly for their antiinflammatory and immunosuppressive effects.
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